Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RPA1 | P27694 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207646 | 0.93 | PTGS2 (0.65) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9208260 | 0.93 | PTGS2 (0.64) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5171748 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1 | |
| Hydrochloric Acid SCHEMBL5147858 | 0.89 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL14504415 | 0.89 | PTGS1 (0.49) | PTGS2PTGS1RPA1ALOX5 | |
| SCHEMBL9210069 | 0.89 | PTGS2 (0.60) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6340846 | 0.88 | PTGS2 (0.75) | PTGS2PTGS1 | |
| SCHEMBL9207837 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL14504421 | 0.88 | PTGS1 (0.48) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9210134 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |