Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 7/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17086632 | 0.83 | MEN1 (0.50) | MAPK14NR3C2KDM5AKDM2BKDM4C | |
| SCHEMBL15503778 | 0.79 | KDM5A (0.51) | MAPK14NR3C2KDM5AKDM2BKDM4C | |
| SCHEMBL25611895 | 0.79 | FLT3 (0.61) | MAPK14NR3C2KDM5AKDM2BKDM4C | |
| SCHEMBL27742800 | 0.79 | MAPK9 (0.51) | MAPK14NR3C2KDM5AKDM2BKDM4C | |
| SCHEMBL9207835 | 0.78 | PTGS2 (0.51) | MAPK14MAPK13MAPK12MAPK11PTGS1 | |
| SCHEMBL8953896 | 0.77 | PTGS2 (0.65) | KDM5AKDM4CKDM5BPTGS1PTGS2 | |
| SCHEMBL5698464 | 0.77 | MAPK14 (0.44) | MAPK14NR3C2KDM5AKDM2BKDM4C | |
| SCHEMBL5698465 | 0.77 | PTGS2 (0.65) | KDM5AKDM4CKDM5BPTGS1PTGS2 | |
| SCHEMBL694620 | 0.76 | KDM5A (0.46) | MAPK14NR3C2KDM5AKDM2BKDM4C | |
| SCHEMBL9202494 | 0.75 | PTGS2 (0.52) | MAPK14MAPK13MAPK12MAPK11PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |