Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9214235 | 0.98 | ADRA1B (0.41) | ADRA1BGRM5PRMT5WDR77ABCB1 | |
| Hydrochloric Acid SCHEMBL9207178 | 0.97 | ADRA1B (0.41) | ADRA1BGRM5PRMT5WDR77HTT | |
| Hydrochloric Acid SCHEMBL9207068 | 0.94 | ADRA1B (0.42) | ADRA1BHTTACHEKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9215384 | 0.92 | PRMT5 (0.40) | ADRA1BPRMT5WDR77KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9213070 | 0.92 | ADRA1B (0.41) | ADRA1BGRM5PRMT5WDR77ABCB1 | |
| SCHEMBL9210433 | 0.90 | PRMT5 (0.41) | ADRA1BPRMT5WDR77KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9213413 | 0.90 | ADRA1B (0.41) | ADRA1BGRM5PRMT5WDR77ABCB1 | |
| SCHEMBL9204857 | 0.90 | ADRA1B (0.40) | ADRA1BGRM5PRMT5WDR77ACHE | |
| Hydrochloric Acid SCHEMBL9215535 | 0.89 | ADRA1B (0.40) | ADRA1BGRM5PRMT5WDR77ACHE | |
| Hydrochloric Acid SCHEMBL9212507 | 0.88 | GRM5 (0.38) | GRM5PRMT5WDR77ABCB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |