Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208832 | 0.99 | GID4 (0.40) | GID4L3MBTL1MAPTPKMHHAT | |
| SCHEMBL9207161 | 0.79 | TSHR (0.53) | GID4L3MBTL1HHATNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL10489402 | 0.77 | TSHR (0.55) | GID4L3MBTL1HHATNPSR1LMNA | |
| SCHEMBL15058181 | 0.77 | GID4 (0.46) | GID4L3MBTL1HHATMAPK1NPSR1 | |
| SCHEMBL4864502 | 0.75 | GID4 (0.48) | GID4L3MBTL1HHATNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL9789702 | 0.74 | GID4 (0.47) | GID4L3MBTL1HHATNPSR1LMNA | |
| SCHEMBL9637825 | 0.73 | GID4 (0.44) | GID4OPRM1MAPK1NPSR1GAA | |
| SCHEMBL9206816 | 0.71 | GID4 (0.43) | GID4L3MBTL1OPRM1OPRD1DRD3 | |
| SCHEMBL9789739 | 0.70 | GID4 (0.43) | GID4L3MBTL1HHATMAPK1NPSR1 | |
| SCHEMBL9209208 | 0.70 | GID4 (0.42) | GID4L3MBTL1OPRM1OPRD1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333427-B1 | Heterocyclic derivatives | SMITHKLINE BEECHAM FARMA (IT) | 1995-08-23 | — | — | EP | claimed |
| EP-0333427-A1 | Heterocyclic derivatives | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1989-09-20 | — | — | EP | claimed |
| EP-0333427-B1 | Heterocyclic derivatives | SMITHKLINE BEECHAM FARMA (IT) | 1995-08-23 | — | — | EP | disclosed |
| US-5109008-A | Analgesics, diuretics, antiischemic agents | GLAXO GROUP LIMITED (GB) | 1992-04-28 | — | — | US | disclosed |
| US-4999359-A | Analgesics | DR. LO ZAMBELETTI S.P.A. (IT) | 1991-03-12 | — | — | US | disclosed |
| EP-0366327-A1 | Furo- and thieno[3,2-c]pyridines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |
| EP-0333427-A1 | Heterocyclic derivatives | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1989-09-20 | — | — | EP | disclosed |