SCHEMBL9208904

SCHEMBL9208904

O=C1N=c2ncccc2=C1Cc1ccncc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.34
TSHR P16473 2/20 0.34
KCNQ2 O43526 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
ALOX15 P16050 1/20 0.34
CYP11B1 P15538 6/20 0.33
CYP11B2 P19099 6/20 0.33
CYP17A1 P05093 5/20 0.33
CYP19A1 P11511 4/20 0.33
POLB P06746 1/20 0.33
LTA4H P09960 1/20 0.33
PLA2G7 Q13093 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
HRH4 Q9H3N8 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9218848 0.98 CYP3A4 (0.33) CYP3A4TSHRKCNQ2CYP1A2CYP2C9
SCHEMBL9260372 0.79 CYP11B1 (0.40) CYP3A4TSHRKCNQ2CYP1A2CYP2C9
SCHEMBL9208908 0.64 CYP11B1 (0.35) CYP3A4TSHRCYP11B1CYP11B2CYP17A1
Hydrochloric Acid SCHEMBL9218850 0.62 CYP11B1 (0.35) CYP3A4CYP11B1CYP11B2CYP17A1CYP19A1
SCHEMBL721736 0.62 CYP17A1 (0.61) CYP3A4TSHRCYP1A2CYP2C9CYP11B1
SCHEMBL1133597 0.61 TDP1 (0.37) CYP3A4TSHRALOX15
SCHEMBL13873567 0.60 CYP17A1 (0.65) CYP3A4TSHRCYP1A2CYP2C9CYP11B1
SCHEMBL2750124 0.60 L3MBTL1 (0.63) CYP1A2ALOX15CYP11B1CYP11B2POLB
SCHEMBL29599407 0.60 TDP1 (0.35) CYP3A4TSHRALOX15
Sibopirdine SCHEMBL120953 0.60 CYP3A4 (0.54) CYP3A4TSHRKCNQ2CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0660833-A1 3,3'-DISUBSTITUTED-1,3-DIHYDRO-2H-PYRROLO 2,3-b]HETEROCYCLIC-2-ONE USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS OF MAN THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-07-05 EP disclosed