Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19215683 | 0.74 | — | — | |
| SCHEMBL6378734 | 0.74 | HRH1 (0.49) | ALDH1A1MAPTTAAR1 | |
| SCHEMBL24535397 | 0.72 | KDM4E (0.40) | ALDH1A1KDM4EGABRA1GABRB2CYP1A2 | |
| SCHEMBL30524385 | 0.72 | KDM4E (0.37) | ALDH1A1KDM4ESMN1; SMN2LMNACYP1A2 | |
| SCHEMBL4777973 | 0.72 | KDM4E (0.50) | ALDH1A1KDM4ESMN1; SMN2LMNACYP1A2 | |
| SCHEMBL7644327 | 0.71 | TDP1 (0.44) | ALDH1A1KDM4ESMN1; SMN2GABRA1GABRB2 | |
| SCHEMBL31300167 | 0.71 | KDM4E (0.46) | KDM4ESMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1240091 | 0.71 | ADRA2A (0.50) | ALDH1A1LMNACYP1A2MAPTHTR1A | |
| SCHEMBL23082861 | 0.71 | CYP2D6 (0.44) | ALDH1A1KDM4EGABRA1GABRB2CYP1A2 | |
| SCHEMBL30551751 | 0.71 | KDM4E (0.48) | ALDH1A1KDM4ESMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654023-A1 | 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003426-A1 | 5-(2-OXYPHENYL)-PYRROLE DERIVATIVES AS DOPAMINE D3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-02-17 | — | — | WO | disclosed |