Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21288425 | 1.00 | THRB (0.50) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL24866063 | 0.96 | THRB (0.47) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL19309256 | 0.96 | THRB (0.47) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL19186535 | 0.96 | THRB (0.47) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL13375646 | 0.96 | THRB (0.47) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL867906 | 0.95 | THRB (0.43) | THRBMEN1KMT2A | |
| Cyclopentanamine SCHEMBL9222 | 0.95 | — | — | |
| SCHEMBL3495069 | 0.95 | THRB (0.43) | THRBMEN1KMT2A | |
| SCHEMBL14665759 | 0.95 | THRB (0.54) | THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL867907 | 0.95 | THRB (0.43) | THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |