Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RPA1 | P27694 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199551 | 1.00 | MEN1 (0.56) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL9204760 | 0.89 | KMT2A (0.72) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL9204658 | 0.89 | KMT2A (0.72) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL9207456 | 0.88 | KMT2A (0.59) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL8642939 | 0.87 | CHRNA7 (0.47) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL9209855 | 0.86 | PTGS1 (0.46) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL9209581 | 0.86 | MEN1 (0.60) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL3865146 | 0.86 | PTGS2 (0.69) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL9208842 | 0.86 | MALT1 (0.65) | MEN1KMT2AATMPTGS2CHRNA7 | |
| SCHEMBL6352446 | 0.85 | PTGS2 (0.67) | PTGS2CHRNA7PTGS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |