Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.49 |
| ▸ | THRA | P10827 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20638641 | 0.77 | SCN8A (0.56) | SCN8ASCN10A | |
| SCHEMBL30752404 | 0.76 | CTNNB1 (0.48) | SCN8ASCN10ACTNNB1WNT3AMAOA | |
| SCHEMBL4115298 | 0.76 | CTNNB1 (0.48) | SCN8ASCN10ACTNNB1WNT3AMAOA | |
| SCHEMBL16741838 | 0.72 | AKR1C3 (0.59) | CTNNB1WNT3AMAOAHDAC1CHEK2 | |
| SCHEMBL8869584 | 0.71 | TTBK1 (0.49) | THRATHRBCDK8CHEK2 | |
| SCHEMBL28917931 | 0.70 | MAOA (0.50) | THRATHRBCTNNB1WNT3AMAOA | |
| SCHEMBL1958280 | 0.70 | CTNNB1 (0.55) | SCN8ASCN10ATHRATHRBCTNNB1 | |
| SCHEMBL30218826 | 0.70 | MAOA (0.50) | THRATHRBCTNNB1WNT3AMAOA | |
| SCHEMBL18941156 | 0.70 | KDM4E (0.54) | THRATHRBCTNNB1WNT3AMAOA | |
| SCHEMBL13548692 | 0.70 | AHR (0.51) | CTNNB1WNT3AMAOAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |