Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12686165 | 0.84 | POLB (0.49) | KMT2AALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL8784255 | 0.81 | MEN1 (0.54) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8783960 | 0.81 | MEN1 (0.54) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8784047 | 0.81 | MEN1 (0.54) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8785078 | 0.81 | MEN1 (0.63) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8153325 | 0.80 | MEN1 (0.58) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL15646869 | 0.80 | HSD17B10 (0.54) | KMT2AALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL19512023 | 0.79 | MEN1 (0.60) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL9098209 | 0.79 | MEN1 (0.52) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL8784073 | 0.78 | KMT2A (0.56) | KMT2AMEN1ALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459561-B1 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME (GB) | 1995-09-20 | — | — | EP | disclosed |
| EP-0459561-A2 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |