Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8832963 | 1.00 | MAPT (0.39) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8832593 | 0.89 | MAPT (0.39) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8832969 | 0.89 | MAPT (0.39) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9220204 | 0.89 | MAPT (0.39) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16024810 | 0.84 | MAPT (0.52) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16023506 | 0.84 | MAPT (0.52) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18387532 | 0.80 | SIGMAR1 (0.42) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1440297 | 0.80 | SIGMAR1 (0.42) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL31309170 | 0.80 | SIGMAR1 (0.42) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1440293 | 0.80 | SIGMAR1 (0.42) | MAPTCHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |