Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | PGR | P06401 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | ELANE | P08246 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28968013 | 0.98 | MAPT (0.67) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL9209028 | 0.92 | NPC1 (0.77) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL27812148 | 0.90 | MAPT (0.67) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL30205105 | 0.89 | NPC1 (0.81) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL3224251 | 0.89 | NPC1 (0.81) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL25304845 | 0.88 | MAPT (0.65) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL4622496 | 0.86 | MAPT (0.66) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL8387178 | 0.85 | MAPT (0.60) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL32672129 | 0.85 | MAPT (0.60) | MAPTMAPK1LMNAALDH1A1HTT | |
| SCHEMBL7468048 | 0.84 | POLB (0.66) | MAPTMAPK1LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437185-B1 | Pyrroline-resp. indoline containing phthalides | CIBA GEIGY AG (CH) | 1995-10-18 | — | — | EP | disclosed |
| EP-0437185-A2 | Pyrroline-resp. indoline containing phthalides | CIBA-GEIGY AG (CH) | 1991-07-17 | — | — | EP | disclosed |