Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211658 | 0.92 | MAPT (0.68) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL28968013 | 0.91 | MAPT (0.67) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL7848712 | 0.87 | LMNA (0.69) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL5902231 | 0.87 | NPC1 (1.00) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL29414999 | 0.87 | NPC1 (1.00) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL18917635 | 0.82 | NPC1 (0.68) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL27812148 | 0.82 | MAPT (0.67) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL10426838 | 0.81 | NPC1 (0.77) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL30205105 | 0.81 | NPC1 (0.81) | NPC1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL3224251 | 0.81 | NPC1 (0.81) | NPC1LMNACYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437185-B1 | Pyrroline-resp. indoline containing phthalides | CIBA GEIGY AG (CH) | 1995-10-18 | — | — | EP | disclosed |
| EP-0437185-A2 | Pyrroline-resp. indoline containing phthalides | CIBA-GEIGY AG (CH) | 1991-07-17 | — | — | EP | disclosed |