Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.72 |
| ▸ | HTR2A | P28223 | 5/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.72 |
| ▸ | DRD3 | P35462 | 4/20 | 0.72 |
| ▸ | HRH1 | P35367 | 4/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.72 |
| ▸ | HTR1A | P08908 | 3/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.72 |
| ▸ | DRD1 | P21728 | 3/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.72 |
| ▸ | HTR2B | P41595 | 3/20 | 0.72 |
| ▸ | HTR3A | P46098 | 3/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9174545 | 0.91 | DRD4 (0.62) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| Fumaric Acid SCHEMBL9174551 | 0.91 | DRD4 (0.62) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| SCHEMBL29384841 | 0.85 | HRH4 (0.59) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| SCHEMBL9181334 | 0.85 | HRH4 (0.59) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| Clothiapine SCHEMBL122941 | 0.84 | DRD2 (1.00) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| Clothiapine SCHEMBL29360219 | 0.84 | DRD2 (1.00) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| SCHEMBL9178906 | 0.81 | HRH4 (0.53) | DRD2ADRA2AHTR2AHRH4DRD4 | |
| SCHEMBL11559143 | 0.78 | DRD2 (0.59) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| SCHEMBL9177207 | 0.76 | DRD4 (1.00) | DRD2ADRA2AHTR2ACHRM1DRD3 | |
| SCHEMBL9213677 | 0.76 | DRD4 (0.78) | DRD2ADRA2AHTR2ACHRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607129-B1 | METHYLPIPERAZINOAZEPINE DERIVATIVES, THEIR PREPARATION AND USE | THERABEL RESEARCH SA (BE) | 1995-08-23 | — | — | EP | claimed |
| EP-0607129-A1 | METHYLPIPERAZINOAZEPINE DERIVATIVES, THEIR PREPARATION AND USE. | THERABEL RESEARCH SA (BE) | 1994-07-27 | — | — | EP | claimed |
| WO-1993007143-A1 | METHYLPIPERAZINOAZEPINE DERIVATIVES, THEIR PREPARATION AND USE | THERABEL RESEARCH S.A./N.V. (BE) | 1993-04-15 | — | — | WO | claimed |
| EP-0607129-B1 | METHYLPIPERAZINOAZEPINE DERIVATIVES, THEIR PREPARATION AND USE | THERABEL RESEARCH SA (BE) | 1995-08-23 | — | — | EP | disclosed |
| EP-0607129-A1 | METHYLPIPERAZINOAZEPINE DERIVATIVES, THEIR PREPARATION AND USE. | THERABEL RESEARCH SA (BE) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993007143-A1 | METHYLPIPERAZINOAZEPINE DERIVATIVES, THEIR PREPARATION AND USE | THERABEL RESEARCH S.A./N.V. (BE) | 1993-04-15 | — | — | WO | disclosed |