SCHEMBL9212207

SCHEMBL9212207

CC1(C)Oc2ccc(C#N)cc2C(O)C1NC(=O)c1ccc(F)cc1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 11/20 0.66
KDM4E B2RXH2 1/20 0.53
RORC P51449 1/20 0.51
ABCB1 P08183 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9212217 1.00 ABCC9 (0.66) ABCC9KDM4ERORCABCB1
SCHEMBL9212195 1.00 ABCC9 (0.66) ABCC9KDM4ERORCABCB1
SCHEMBL9216502 0.90 ABCC9 (0.60) ABCC9KDM4EABCB1
SCHEMBL9216510 0.90 ABCC9 (0.60) ABCC9KDM4EABCB1
SCHEMBL9216497 0.90 ABCC9 (0.60) ABCC9KDM4EABCB1
SCHEMBL9221479 0.89 ABCC9 (0.65) ABCC9KDM4EABCB1
SCHEMBL9221502 0.89 ABCC9 (0.65) ABCC9KDM4EABCB1
SCHEMBL9221492 0.89 ABCC9 (0.65) ABCC9KDM4EABCB1
SCHEMBL7479202 0.86 ABCC9 (0.88) ABCC9KDM4EABCB1
SCHEMBL7481849 0.86 ABCC9 (0.88) ABCC9KDM4EABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0375449-B1 Benzopyran-type compounds BEECHAM GROUP PLC (GB) 1995-02-15 EP claimed
EP-0375449-A2 Benzopyran-type compounds BEECHAM GROUP PLC (GB) 1990-06-27 EP claimed
EP-0375449-B1 Benzopyran-type compounds BEECHAM GROUP PLC (GB) 1995-02-15 EP disclosed
EP-0375449-A2 Benzopyran-type compounds BEECHAM GROUP PLC (GB) 1990-06-27 EP disclosed