Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108514 | 0.92 | ALOX5AP (0.85) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL8559592 | 0.90 | ALOX5AP (0.72) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9389826 | 0.90 | ALOX5AP (0.81) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL8559127 | 0.90 | PTGS1 (0.75) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9185735 | 0.89 | ALOX5AP (0.86) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9212757 | 0.88 | ALOX5AP (0.75) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL3504642 | 0.86 | ALOX5AP (0.82) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2109184 | 0.86 | ALOX5AP (0.82) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL9393641 | 0.86 | ALOX5AP (0.82) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 | |
| SCHEMBL2108390 | 0.84 | ALOX5AP (0.80) | ALOX5APPTGS1PTGS2ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| US-5272145-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-12-21 | — | — | US | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |