Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.82 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3504642 | 0.98 | ALOX5AP (0.82) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2108514 | 0.93 | ALOX5AP (0.85) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2109184 | 0.91 | ALOX5AP (0.82) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL9389826 | 0.90 | ALOX5AP (0.81) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2108478 | 0.90 | ALOX5AP (1.00) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2108390 | 0.90 | ALOX5AP (0.80) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2107877 | 0.88 | PTGS1 (0.86) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL9048306 | 0.88 | ALOX5AP (0.84) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2108907 | 0.87 | PTGS1 (0.87) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2108396 | 0.87 | ALOX5AP (0.83) | ALOX5APALOX5PTGS1PTGS2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994013293-A2 | (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | claimed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | claimed |