Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210766 | 0.79 | HCAR2 (0.31) | — | |
| SCHEMBL4386400 | 0.78 | KMT2A (0.42) | CYP2C19CTSDL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9210430 | 0.77 | CFTR (0.44) | SLC6A2SLC6A4SLC6A3CYP19A1L3MBTL1 | |
| SCHEMBL6632699 | 0.71 | CYP3A4 (0.43) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| Sulfuric Acid SCHEMBL28064136 | 0.68 | HPGD (0.34) | SLC6A2SLC6A4SLC6A3CYP19A1KDM4E | |
| SCHEMBL9212907 | 0.68 | — | — | |
| SCHEMBL29235892 | 0.67 | GAA (0.41) | CYP3A4GAACTSDALDH1A1MDM2 | |
| SCHEMBL8463112 | 0.66 | SLC6A2 (0.55) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL242307 | 0.66 | SLC6A2 (0.42) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27856382 | 0.64 | FFAR2 (0.40) | CYP3A4CYP2C19CYP19A1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508549-B1 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO CO (JP) | 1995-04-26 | — | — | EP | disclosed |
| EP-0347252-B1 | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| EP-0508549-A2 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO COMPANY LIMITED (JP) | 1992-10-14 | — | — | EP | disclosed |
| US-5086057-A | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1992-02-04 | — | — | US | disclosed |
| US-5055479-A | For enhancing activity of lipoprotein lipase enzymes | SANKYO COMPANY, LIMITED (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0347252-A2 | Method of treating cachexia and certain new compounds for use in this method | SANKYO COMPANY LIMITED (JP) | 1989-12-20 | — | — | EP | disclosed |