Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211468 | 0.96 | PRMT5 (0.41) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| SCHEMBL9206642 | 0.95 | PRMT5 (0.40) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| Hydrochloric Acid SCHEMBL9212963 | 0.95 | PRMT5 (0.40) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| SCHEMBL9215245 | 0.93 | ALDH1A1 (0.41) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| SCHEMBL9206673 | 0.90 | PRMT5 (0.38) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| SCHEMBL9210433 | 0.88 | PRMT5 (0.41) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| Hydrochloric Acid SCHEMBL9215384 | 0.87 | PRMT5 (0.40) | ALDH1A1KDM4ERAD52NPSR1GAA | |
| SCHEMBL9208294 | 0.86 | PRMT5 (0.42) | PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL9206928 | 0.86 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL9216938 | 0.85 | PRMT5 (0.40) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |