Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 15/20 | 0.67 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.40 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.40 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.40 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24747276 | 0.86 | RYR2 (0.49) | RYR2GSK3BKCNH2KMT2AMEN1 | |
| SCHEMBL6866946 | 0.81 | RYR2 (0.72) | RYR2 | |
| SCHEMBL6867029 | 0.80 | RYR2 (1.00) | RYR2KCNH2NOTUM | |
| SCHEMBL7560987 | 0.80 | RYR2 (0.72) | RYR2KCNH2NOTUM | |
| SCHEMBL6866477 | 0.80 | RYR2 (0.72) | RYR2KCNH2NOTUM | |
| SCHEMBL9635059 | 0.80 | RYR2 (0.72) | RYR2KCNH2NOTUM | |
| SCHEMBL13622149 | 0.79 | RYR2 (0.71) | RYR2KCNH2KMT2AMEN1 | |
| SCHEMBL15672246 | 0.79 | RYR2 (0.65) | RYR2KCNH2 | |
| SCHEMBL3427146 | 0.78 | RYR2 (1.00) | RYR2 | |
| SCHEMBL13622102 | 0.78 | RYR2 (0.78) | RYR2KCNH2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4230681-A | — | — | None | — | — | JP | disclosed |
| EP-0565721-B1 | 1,4-BENZOTHIAZEPINE DERIVATIVE | KANEKO NOBORU (JP) | 1995-07-26 | — | — | EP | disclosed |
| US-5416066-A | FOR THE PREVENTION OF MYOCARDIAL INFARCTION OR INHIBITING MYOCARDIAL NECROSIS | KIRIN BREWERY CO., LTD. (JP) | 1995-05-16 | — | — | US | disclosed |
| EP-0565721-A1 | 1,4-BENZOTHIAZEPINE DERIVATIVE | KANEKO, Noboru (JP) | 1993-10-20 | — | — | EP | disclosed |
| JP-H04230681-A | 1,4-BENZOTHIAZEPINE DERIVATIVE | KIRIN BREWERY CO LTD | 1992-08-19 | — | — | JP | disclosed |