Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584861 | 0.88 | LMNA (0.49) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9212081 | 0.88 | LMNA (0.49) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9215078 | 0.80 | MEN1 (0.56) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9318982 | 0.79 | LMNA (0.51) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL8361113 | 0.77 | LMNA (0.77) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL10453095 | 0.76 | LMNA (0.62) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9001814 | 0.76 | LMNA (0.66) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL14709544 | 0.76 | HPGD (0.43) | LMNASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2230656 | 0.76 | SLC6A4 (0.68) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9583437 | 0.75 | MEN1 (0.54) | LMNAKDM4EMEN1ALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670838-A1 | SUBSTITUTED-PHENYL(N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE)-1H/3H-IMIDAZO 4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5359073-A | Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists | G. D. SEARLE & CO. (US) | 1994-10-25 | — | — | US | disclosed |
| WO-1994012500-A1 | SUBSTITUTED-PHENYL(N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE)-1H/3H-IMIDAZO[4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1994-06-09 | — | — | WO | disclosed |
| US-5302601-A | Useful in the treatment of diseases mediated by platelet activating factor | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |