Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CDC25A | P30304 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712301 | 0.89 | NR4A1 (0.68) | NR4A1KDM4EALDH1A1TP53TSHR | |
| SCHEMBL30704729 | 0.88 | NR4A1 (0.66) | NR4A1KDM4EALDH1A1SMN1; SMN2CDC25A | |
| SCHEMBL9197822 | 0.88 | NR4A1 (0.66) | NR4A1KDM4EALDH1A1SMN1; SMN2CDC25A | |
| SCHEMBL9207086 | 0.87 | POLB (0.69) | NR4A1KDM4EALDH1A1TP53TSHR | |
| SCHEMBL11731147 | 0.84 | NR4A1 (0.70) | NR4A1KDM4EALDH1A1TP53TSHR | |
| SCHEMBL3956037 | 0.82 | NR4A1 (0.68) | NR4A1KDM4EALDH1A1TP53TSHR | |
| SCHEMBL11851861 | 0.82 | SRD5A2 (0.62) | KDM4EALDH1A1TP53TSHRCASP1 | |
| SCHEMBL28157462 | 0.82 | NR4A1 (0.61) | NR4A1KDM4EALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL10940788 | 0.81 | ALOX15 (0.54) | NR4A1ALDH1A1ALOX15PARP1POLB | |
| SCHEMBL16363711 | 0.81 | POLB (0.60) | NR4A1ALDH1A1TP53CDC25ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569457-B1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- [2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0569457-A1 | USE OF THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992013863-A1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-20 | — | — | WO | disclosed |