Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214617 | 1.00 | LMNA (0.44) | LMNAKMT2ATDP1RAB9AEPHX2 | |
| Hydrochloric Acid SCHEMBL9211425 | 0.99 | LMNA (0.43) | LMNAKMT2ATDP1RAB9AEPHX2 | |
| Hydrochloric Acid SCHEMBL9211420 | 0.99 | LMNA (0.43) | LMNAKMT2ATDP1RAB9AEPHX2 | |
| SCHEMBL9211713 | 0.83 | EPHX2 (0.46) | LMNAKMT2AEPHX2NAMPTHTT | |
| SCHEMBL9211715 | 0.83 | EPHX2 (0.46) | LMNAKMT2AEPHX2NAMPTHTT | |
| Hydrochloric Acid SCHEMBL9218712 | 0.82 | EPHX2 (0.45) | LMNAEPHX2NAMPTHTTTBXA2R | |
| Hydrochloric Acid SCHEMBL9218717 | 0.82 | EPHX2 (0.45) | LMNAEPHX2NAMPTHTTTBXA2R | |
| SCHEMBL9597225 | 0.80 | LMNA (0.51) | LMNAKMT2ATDP1RAB9AHTT | |
| SCHEMBL9214627 | 0.80 | LMNA (0.42) | LMNAKMT2ATDP1RAB9AEPHX2 | |
| Hydrochloric Acid SCHEMBL10435075 | 0.79 | LMNA (0.50) | LMNAKMT2ATDP1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | claimed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | claimed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |