Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL9214704 | 0.93 | TSHR (0.60) | TSHRNAPRTTDP1TAAR1NOTUM | |
| Pyridine SCHEMBL8017674 | 0.86 | NAPRT (0.69) | TSHRNAPRTTDP1TAAR1NOTUM | |
| Pyridine SCHEMBL29050810 | 0.86 | NAPRT (0.69) | TSHRNAPRTTDP1TAAR1NOTUM | |
| Pyridine SCHEMBL5412930 | 0.86 | TSHR (0.69) | TSHRNAPRTTDP1NOTUM | |
| Pyridine SCHEMBL28266003 | 0.83 | TSHR (0.64) | TSHRNAPRTTDP1TAAR1NOTUM | |
| Pyridine SCHEMBL4636073 | 0.82 | — | — | |
| Pyridine SCHEMBL31396433 | 0.82 | — | — | |
| Pyridine SCHEMBL28067297 | 0.82 | NAPRT (0.90) | TSHRNAPRTTDP1TAAR1NOTUM | |
| Pyridine SCHEMBL6532110 | 0.82 | — | — | |
| Pyridine SCHEMBL8733420 | 0.79 | NAPRT (0.69) | TSHRNAPRTTDP1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333427-B1 | Heterocyclic derivatives | SMITHKLINE BEECHAM FARMA (IT) | 1995-08-23 | — | — | EP | claimed |
| EP-0333427-A1 | Heterocyclic derivatives | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1989-09-20 | — | — | EP | claimed |
| EP-0333427-B1 | Heterocyclic derivatives | SMITHKLINE BEECHAM FARMA (IT) | 1995-08-23 | — | — | EP | disclosed |
| EP-0333427-A1 | Heterocyclic derivatives | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1989-09-20 | — | — | EP | disclosed |