Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214757 | 0.81 | NPC1 (0.54) | NPC1RAB9AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL9219309 | 0.81 | MAPT (0.51) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL1181029 | 0.80 | NPC1 (0.87) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6352561 | 0.80 | RAB9A (0.61) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL9212438 | 0.79 | RAB9A (0.56) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL9213944 | 0.79 | RAB9A (0.59) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL1144008 | 0.79 | NPC1 (0.59) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6352556 | 0.79 | NPC1 (0.59) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL10583890 | 0.79 | RAB9A (0.59) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL1221306 | 0.78 | MAPT (0.66) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446010-B1 | Imidazole derivatives and antiepileptics comprising said imidazole derivatives as effective ingredients | MITSUI TOATSU CHEMICALS (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5112841-A | Anticonvulsants | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-12 | — | — | US | disclosed |
| EP-0446010-A1 | Imidazole derivatives and antiepileptics comprising said imidazole derivatives as effective ingredients | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-09-11 | — | — | EP | disclosed |