Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983109 | 0.73 | KMT2A (0.50) | KMT2AALDH1A1MEN1CYP1A2THRB | |
| SCHEMBL8459977 | 0.71 | ALDH1A1 (0.41) | NR4A2KMT2AALDH1A1HPGDGAA | |
| SCHEMBL3943718 | 0.70 | CYP2C19 (0.44) | KMT2AALDH1A1MEN1CYP1A2HPGD | |
| SCHEMBL15104417 | 0.69 | SMN1; SMN2 (0.47) | NR4A2KMT2AALDH1A1MEN1CYP1A2 | |
| SCHEMBL6499020 | 0.69 | POLB (0.55) | KMT2AALDH1A1MEN1CYP1A2HPGD | |
| SCHEMBL13460050 | 0.68 | KMT2A (0.52) | NR4A2KMT2AMEN1HDAC1HDAC6 | |
| SCHEMBL22147214 | 0.68 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1CYP1A2HPGD | |
| SCHEMBL6279720 | 0.68 | NR1H3 (0.50) | KMT2AALDH1A1HPGDHSD11B1POLB | |
| Succinic Acid SCHEMBL27852517 | 0.68 | NR4A2 (0.57) | NR4A2KMT2AALDH1A1MEN1CYP1A2 | |
| SCHEMBL12360014 | 0.66 | POLB (0.47) | KMT2AALDH1A1HPGDHSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2104587-A | — | — | None | — | — | JP | disclosed |
| EP-0344922-B1 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | UNIV PRINCETON (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0344922-A3 | N-(N-(TETRAHYDROPYRIDO(2,3-D)PYRIMIDINYLMETHYL)-AMINOMETHYLBENZOYL)GLUTAMIC ACID DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-05 | — | — | EP | disclosed |
| JP-H02104587-A | N-(N-(TETRAHYDROPYRIDO(2,3-D)PYRIMIDINYLMETHYL) AMINOMETHYLBENZOYL)GLUTAMIC ACID DERIVATIVE | UNIV PRINCETON | 1990-04-17 | — | — | JP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |