Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263724 | 1.00 | NPC1 (0.40) | NPC1ALDH1A1CYP2D6CYP2C19GRM2 | |
| SCHEMBL30821345 | 0.86 | NPC1 (0.43) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL15901285 | 0.86 | NPC1 (0.43) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL4190714 | 0.81 | KDM4E (0.50) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL6608831 | 0.81 | GRM2 (0.42) | NPC1ALDH1A1CYP2D6CYP2C19GRM2 | |
| SCHEMBL449353 | 0.81 | NPC1 (0.44) | NPC1ALDH1A1CYP2D6CYP2C19GRM2 | |
| SCHEMBL7453009 | 0.81 | SOAT1 (0.49) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL4885285 | 0.81 | SOAT1 (0.49) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL21494430 | 0.81 | SOAT1 (0.49) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL3221935 | 0.81 | SOAT1 (0.49) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680472-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995014673-A1 | 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR | PHARMACIA S.P.A. (IT) | 1995-06-01 | — | — | WO | disclosed |