Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206714 | 0.80 | HSD11B1 (0.38) | NPC1POLBHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL9212291 | 0.78 | NPC1 (0.37) | NPC1POLBOPRL1HTTSMN1; SMN2 | |
| SCHEMBL9216390 | 0.78 | RXFP1 (0.41) | NPC1POLBHTTSMN1; SMN2PARP1 | |
| SCHEMBL9123045 | 0.77 | NPC1 (0.50) | NPC1POLBHTTSMN1; SMN2PARP1 | |
| SCHEMBL9222286 | 0.77 | NPC1 (0.50) | NPC1POLBHTTSMN1; SMN2PARP1 | |
| SCHEMBL9213175 | 0.77 | NPC1 (0.50) | NPC1POLBHTTSMN1; SMN2PARP1 | |
| SCHEMBL9209781 | 0.77 | NPC1 (0.34) | NPC1POLBHTTSMN1; SMN2PARP1 | |
| SCHEMBL9213340 | 0.76 | NPC1 (0.36) | NPC1POLBHSD17B10HTTSMN1; SMN2 | |
| SCHEMBL9209672 | 0.75 | POLB (0.40) | NPC1POLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL9739760 | 0.75 | OPRL1 (0.38) | NPC1POLBOPRL1HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569457-B1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- [2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0569457-A1 | USE OF THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992013863-A1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-20 | — | — | WO | disclosed |