Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 8/20 | 0.53 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15345915 | 0.87 | LMNA (0.46) | LMNATP53IKBKETBK1ALDH1A1 | |
| SCHEMBL28784797 | 0.85 | LMNA (0.64) | LMNATP53PIM1IKBKETBK1 | |
| SCHEMBL9216346 | 0.82 | CA12 (0.51) | LMNATP53ALDH1A1MAPK1MEN1 | |
| SCHEMBL5557680 | 0.81 | LMNA (0.63) | LMNATP53PIM1ALDH1A1TBXAS1 | |
| SCHEMBL9613247 | 0.80 | LMNA (0.69) | LMNATP53PIM1ALDH1A1TBXAS1 | |
| SCHEMBL12319491 | 0.78 | DYRK1A (0.41) | LMNATP53IKBKETBK1GRIN2D | |
| SCHEMBL21697981 | 0.78 | LMNA (0.67) | LMNATP53PIM1ALDH1A1TBXAS1 | |
| SCHEMBL25146510 | 0.77 | LMNA (0.55) | LMNATP53PIM1IKBKETBK1 | |
| SCHEMBL11493953 | 0.77 | LMNA (0.66) | LMNATP53PIM1ALDH1A1TBXAS1 | |
| SCHEMBL9211966 | 0.77 | HPGD (0.50) | TSHRHPGDTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |