Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 18/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215584 | 0.89 | AKR1B1 (0.77) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| Ponalrestat SCHEMBL30350285 | 0.89 | AKR1B1 (1.00) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9216690 | 0.89 | AKR1B1 (0.77) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| Ponalrestat SCHEMBL49154 | 0.89 | AKR1B1 (1.00) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9207145 | 0.89 | AKR1B1 (0.73) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| Ponalrestat SCHEMBL29498248 | 0.89 | AKR1B1 (1.00) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9215600 | 0.85 | AKR1B1 (0.71) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9217271 | 0.85 | ALDH1A1 (0.67) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9216689 | 0.83 | KMT2A (0.72) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9218891 | 0.79 | AKR1B1 (0.66) | AKR1B1MEN1CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995003053-A1 | OXOPHTHALAZINES FOR TREATING CACHEXIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-02 | — | — | WO | disclosed |