Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 18/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.58 |
| ▸ | PTGES | O14684 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212529 | 0.91 | PTGES2 (0.62) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL2108941 | 0.82 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9PTGS2 | |
| SCHEMBL9146239 | 0.79 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL30181605 | 0.79 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL1723700 | 0.77 | ALOX5AP (0.56) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL25968193 | 0.75 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL9044519 | 0.75 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL9458425 | 0.75 | PTGES2 (0.77) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL503001 | 0.74 | PTGES2 (1.00) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 | |
| SCHEMBL29351963 | 0.74 | PTGES2 (1.00) | ALOX5APALOX5CYP3A4CYP2C9PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| WO-1994013293-A2 | (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
| US-5272145-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-12-21 | — | — | US | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| EP-0419049-A1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1991-03-27 | — | — | EP | disclosed |