Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 13/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.56 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | BLM | P54132 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | PTGES | O14684 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193211 | 0.80 | ALOX5 (0.85) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL9218685 | 0.77 | ALOX5AP (0.69) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL9212529 | 0.76 | PTGES2 (0.62) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL9185228 | 0.74 | ALOX5AP (0.39) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL29351963 | 0.72 | PTGES2 (1.00) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL503001 | 0.72 | PTGES2 (1.00) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL16857038 | 0.70 | ALOX5 (1.00) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL9721017 | 0.70 | PTGES2 (0.51) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL1723699 | 0.70 | PTGES2 (0.46) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL13447685 | 0.70 | ALOX5 (0.81) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404904-A1 | 5-lipoxygenase-activating protein (FLAP) inhibitors | Amira Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |