Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | FYN | P06241 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KIF5B | P33176 | 1/20 | 0.42 |
| ▸ | ETV6 | P41212 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220988 | 0.90 | MAPT (0.45) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9218703 | 0.90 | MAPT (0.48) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9215050 | 0.87 | MAPT (0.43) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9219409 | 0.86 | SMPD3 (0.41) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9221092 | 0.85 | FYN (0.43) | MAPTFYNGAAKDRPIK3CD | |
| SCHEMBL9218344 | 0.85 | MAPT (0.41) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8993192 | 0.83 | FYN (0.41) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9217924 | 0.82 | KMT2A (0.54) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL8992897 | 0.82 | FYN (0.41) | MAPTFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9172328 | 0.82 | FYN (0.40) | MAPTFYNSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |