Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 3/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221092 | 0.90 | FYN (0.43) | MAPTFYN | |
| SCHEMBL9219353 | 0.86 | MAPT (0.56) | MAPTFYNGAKMEN1NPC1 | |
| SCHEMBL9215969 | 0.84 | CYP1A1 (0.42) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9220988 | 0.84 | MAPT (0.45) | MAPTFYNGAKMEN1NPC1 | |
| SCHEMBL9218703 | 0.82 | MAPT (0.48) | MAPTFYNGAKMEN1NPC1 | |
| SCHEMBL9215050 | 0.81 | MAPT (0.43) | MAPTFYNGAKMEN1NPC1 | |
| SCHEMBL9221145 | 0.80 | CYP17A1 (0.36) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9219419 | 0.80 | ALDH1A1 (0.34) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL9218344 | 0.80 | MAPT (0.41) | SMPD3MAPTFYNGAKMEN1 | |
| SCHEMBL9217924 | 0.79 | KMT2A (0.54) | MAPTMEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |