Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21235768 | 0.95 | HDAC6 (0.42) | HDAC6HDAC1HDAC2CA14MAOA | |
| SCHEMBL8383405 | 0.91 | HDAC6 (0.38) | HDAC6HDAC1HDAC2CA14MAOA | |
| SCHEMBL6256081 | 0.85 | HDAC6 (0.40) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL693386 | 0.85 | HDAC6 (0.40) | HDAC6HDAC1HDAC2CA14BUB1 | |
| SCHEMBL23477345 | 0.84 | HDAC6 (0.39) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL9227134 | 0.84 | HDAC6 (0.46) | HDAC6HDAC1HDAC2CA14AAK1 | |
| SCHEMBL2344511 | 0.84 | HDAC6 (0.39) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL55404 | 0.83 | HDAC6 (0.38) | HDAC6HDAC1HDAC2CA14AAK1 | |
| SCHEMBL2020494 | 0.82 | TSHR (0.47) | HDAC6HDAC1HDAC2CA14CTSK | |
| SCHEMBL734219 | 0.82 | HDAC6 (0.38) | HDAC6HDAC1HDAC2CA14CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777069-B2 | Prodrugs of carbamate inhibitors of IMPDH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-17 | — | — | US | disclosed |
| US-7777069-B2 | Prodrugs of carbamate inhibitors of IMPDH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090093639-A1 | Prodrugs of carbamate inhibitors of IMPDH | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2009-04-09 | — | — | US | disclosed |
| US-20090093639-A1 | Prodrugs of carbamate inhibitors of IMPDH | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2009-04-09 | — | — | US | disclosed |
| EP-0639582-A2 | Polynucleotide assay reagent and method | ANTIVIRALS INC. (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5217866-A | Polynucleotide assay reagent and method | ANTI-GENE DEVELOPMENT GROUP (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0215942-A4 | POLYNUCLEOTIDE ASSAY REAGENT AND METHOD. | SUMMERTON JAMES | 1988-08-23 | — | — | EP | disclosed |
| EP-0215942-A1 | POLYNUCLEOTIDE ASSAY REAGENT AND METHOD. | SUMMERTON JAMES | 1987-04-01 | — | — | EP | disclosed |
| WO-1986005519-A1 | POLYNUCLEOTIDE ASSAY REAGENT AND METHOD | SUMMERTON JAMES | 1986-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093639-A1 | Prodrugs of carbamate inhibitors of IMPDH | IMPDH1, IMPDH2, IMPA1 | HDAC6 618/4885HDAC1 170/4885HDAC2 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.