Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 12/20 | 0.47 |
| ▸ | LDLR | P01130 | 9/20 | 0.47 |
| ▸ | PCSK9 | Q8NBP7 | 9/20 | 0.47 |
| ▸ | ABL1 | P00519 | 8/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9284878 | 0.87 | PSEN1 (0.53) | KITLDLRPCSK9ABL1PDGFRB | |
| SCHEMBL9229486 | 0.74 | PSEN1 (0.46) | CYP3A4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9226835 | 0.71 | PSEN1 (0.43) | CYP3A4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9221594 | 0.70 | PSEN1 (0.47) | CYP3A4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1653907 | 0.68 | ABL1 (0.75) | KITLDLRPCSK9ABL1PDGFRB | |
| SCHEMBL3530581 | 0.68 | ABL1 (0.74) | KITLDLRPCSK9ABL1PDGFRB | |
| SCHEMBL19404656 | 0.66 | ABL1 (0.85) | KITLDLRPCSK9ABL1PDGFRB | |
| SCHEMBL20144388 | 0.66 | BRAF (0.50) | KITLDLRPCSK9ABL1BCR | |
| SCHEMBL16469666 | 0.66 | ABL1 (0.72) | KITLDLRPCSK9ABL1PDGFRB | |
| SCHEMBL6853609 | 0.66 | PSEN1 (0.65) | CYP3A4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946266-B2 | Substituted triazole and imidazole derivatives as gamma secretase modulators | Janssen Pharmaceuticals, Inc. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20120135981-A1 | NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | CELLZOME LIMITED (GB) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135981-A1 | NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, APH1A | KIT 1382/4885LDLR 1718/4885PCSK9 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.