Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9278014 | 0.92 | HRH3 (0.61) | HRH3KCNH2LTA4HACKR3ACHE | |
| SCHEMBL9212788 | 0.81 | HRH3 (0.78) | HRH3KCNH2LTA4HACKR3MAPK1 | |
| SCHEMBL9217275 | 0.78 | HRH3 (0.65) | HRH3KCNH2LTA4HACKR3HRH1 | |
| SCHEMBL9214015 | 0.78 | HRH3 (0.65) | HRH3KCNH2LTA4HACKR3HRH1 | |
| SCHEMBL9213571 | 0.76 | HRH3 (0.65) | HRH3KCNH2LTA4HACKR3RAB9A | |
| SCHEMBL9668080 | 0.76 | HRH3 (0.68) | HRH3KCNH2LTA4HACKR3RAB9A | |
| SCHEMBL9211677 | 0.76 | HRH3 (0.65) | HRH3KCNH2LTA4HACKR3HRH1 | |
| SCHEMBL9211253 | 0.76 | HRH3 (0.65) | HRH3KCNH2LTA4HACKR3HRH1 | |
| SCHEMBL3574322 | 0.76 | HRH3 (0.86) | HRH3KCNH2ACHERAD52HRH1 | |
| SCHEMBL4237405 | 0.75 | LTA4H (0.72) | HRH3KCNH2LTA4HACHERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320032-B1 | Pyridizinamine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-01-18 | — | — | EP | disclosed |
| US-5106973-A | Viricide intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-21 | — | — | US | disclosed |
| US-4992433-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-12 | — | — | US | disclosed |