2-Pyrrolidone

2-Pyrrolidone

SCHEMBL9219915

CC(=O)Nc1nc2nc[nH]c2c(=O)[nH]1.O=C1CCCN1

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.75
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
POLA1 P09884 1/20 0.46
XDH P47989 3/20 0.46
FGFR1 P11362 1/20 0.44
FGFR2 P21802 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL219478 0.87 GDA (1.00) GDAKDM4EGAAPOLA1XDH
SCHEMBL9581457 0.82 GDA (0.89) GDAKDM4EGAAPOLA1XDH
Guanine SCHEMBL9220514 0.77 PNP (0.70) GDAKDM4EPOLA1
SCHEMBL19466100 0.75 GDA (0.76) GDAPOLA1XDH
SCHEMBL29411658 0.75 GDA (0.76) GDAPOLA1XDH
SCHEMBL28559767 0.74 GDA (0.75) GDAPOLA1XDH
SCHEMBL31093422 0.74 GDA (0.74) GDAPOLA1XDH
SCHEMBL6821775 0.73 GDA (0.74) GDAPOLA1XDH
SCHEMBL30510976 0.73 GDA (0.74) GDAPOLA1XDH
SCHEMBL735411 0.73 GDA (0.72) GDAXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215942-B1 POLYNUCLEOTIDE ASSAY REAGENT AND METHOD ANTIVIRALS INC (US) 1995-07-12 EP disclosed
EP-0639582-A2 Polynucleotide assay reagent and method ANTIVIRALS INC. (US) 1995-02-22 EP disclosed
US-5217866-A Polynucleotide assay reagent and method ANTI-GENE DEVELOPMENT GROUP (US) 1993-06-08 US disclosed
EP-0216860-B1 STEREOREGULAR POLYNUCLEOTIDE-BINDING POLYMERS SUMMERTON, James (US) 1992-10-28 EP disclosed
EP-0216860-A4 STEREOREGULAR POLYNUCLEOTIDE-BINDING POLYMERS. SUMMERTON JAMES (US) 1989-02-22 EP disclosed
EP-0215942-A4 POLYNUCLEOTIDE ASSAY REAGENT AND METHOD. SUMMERTON JAMES 1988-08-23 EP disclosed
EP-0216860-A1 STEREOREGULAR POLYNUCLEOTIDE-BINDING POLYMERS. SUMMERTON JAMES (US) 1987-04-08 EP disclosed
EP-0215942-A1 POLYNUCLEOTIDE ASSAY REAGENT AND METHOD. SUMMERTON JAMES 1987-04-01 EP disclosed
WO-1986005518-A1 STEREOREGULAR POLYNUCLEOTIDE-BINDING POLYMERS SUMMERTON JAMES 1986-09-25 WO disclosed
WO-1986005519-A1 POLYNUCLEOTIDE ASSAY REAGENT AND METHOD SUMMERTON JAMES 1986-09-25 WO disclosed