Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoxepac SCHEMBL29588437 | 0.88 | AKR1B1 (0.81) | AKR1B1ALDH1A1MAPTRAB9A | |
| Isoxepac SCHEMBL24970 | 0.88 | AKR1B1 (0.81) | AKR1B1ALDH1A1MAPTRAB9A | |
| SCHEMBL342988 | 0.87 | AKR1B1 (0.63) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12796661 | 0.87 | ALDH1A1 (0.63) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL243707 | 0.85 | AKR1B1 (0.60) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4008419 | 0.84 | ALDH1A1 (0.60) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL10565046 | 0.84 | ALDH1A1 (0.61) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13870524 | 0.83 | ALDH1A1 (0.67) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13538726 | 0.83 | ALDH1A1 (0.59) | AKR1B1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9216642 | 0.83 | AKR1B1 (0.58) | AKR1B1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419844-B1 | N-hydroxy-dibenz[b,e]oxepin-alkylamines and -alkanoic acid amides, related heterocyclic analogues, a process for their preparation and their use in the manufacture of medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0419844-A1 | N-hydroxy-dibenz[b,e]oxepin-alkylamines and -alkanoic acid amides, related heterocyclic analogues, a process for their preparation and their use in the manufacture of medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4816591-A | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives | AMERICAN HOECHST CORPORATION (US) | 1989-03-28 | — | — | US | disclosed |
| US-4585788-A | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives | AMERICAN HOECHST CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| US-4576960-A | 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives | HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-03-18 | — | — | US | disclosed |
| US-4515946-A | 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-05-07 | — | — | US | disclosed |
| EP-0082521-A1 | 6,11-Dihydro-11,-oxo-dibenz(b,e)-oxepin derivatives, methods for their preparation, pharmaceutical compositions containing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-06-29 | — | — | EP | disclosed |