Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444964 | 1.00 | LDHA (0.56) | LDHAPPARGKMT2APPARAPOLB | |
| SCHEMBL9219968 | 1.00 | LDHA (0.56) | LDHAPPARGKMT2APPARAPOLB | |
| SCHEMBL9226473 | 0.84 | PPARA (0.48) | PPARGKMT2APPARA | |
| SCHEMBL9226476 | 0.84 | PPARA (0.48) | PPARGKMT2APPARA | |
| SCHEMBL7269232 | 0.84 | CYP1A2 (0.59) | — | |
| SCHEMBL7163321 | 0.84 | CYP1A2 (0.59) | — | |
| SCHEMBL7277365 | 0.84 | CYP1A2 (0.59) | — | |
| SCHEMBL10436394 | 0.82 | LDHA (0.76) | LDHAPPARGKMT2APPARAPOLB | |
| SCHEMBL8531043 | 0.80 | CYP1A2 (0.42) | — | |
| SCHEMBL12494157 | 0.79 | LDHA (0.71) | LDHAPPARGKMT2APPARAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |