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SCHEMBL9220910

SCHEMBL9220910

C[SiH](C)[C@@]1(n2cc(F)c(=O)[nH]c2=O)O[C@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H](O)[C@H]1OC(C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ HSP90AA1 P07900 1/20 0.42
▸ TK1 P04183 8/20 0.34
▸ TYMP P19971 5/20 0.34
▸ TK2 O00142 7/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9228434 0.89 HSP90AA1 (0.42) HSP90AA1TK1TYMPTK2
SCHEMBL9219810 0.89 HSP90AA1 (0.43) HSP90AA1TK1TYMPTK2
SCHEMBL9226219 0.84 LMNA (0.39) TK1TK2
SCHEMBL6363039 0.81 TYMP (0.40) TYMP
SCHEMBL9229159 0.81 LMNA (0.35) HSP90AA1
SCHEMBL10646812 0.75 — —
SCHEMBL31548917 0.75 P2RY2 (0.36) —
SCHEMBL9226559 0.75 TYMS (0.36) HSP90AA1TK1
SCHEMBL10647181 0.75 — —
SCHEMBL9227559 0.74 LMNA (0.39) TK1TK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5420117-A Antitumor agents TAIHO PHARMACEUTICAL CO., LTD. (JP) 1995-05-30 — — US disclosed
EP-0378706-B1 5-SUBSTITUTED URIDINE DERIVATIVES AND INTERMEDIATES FOR THEIR PREPARATION TAIHO PHARMACEUTICAL CO LTD (JP) 1994-12-28 — — EP disclosed
EP-0378706-A1 5-SUBSTITUTED URIDINE DERIVATIVES AND INTERMEDIATES FOR THEIR PREPARATION TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1990-07-25 — — EP disclosed