Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | UBE2M | P61081 | 5/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227832 | 0.90 | NPSR1 (0.45) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL4106190 | 0.90 | NPSR1 (0.45) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL29427715 | 0.90 | NPSR1 (0.45) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL9220965 | 0.88 | GAA (0.49) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL8808845 | 0.88 | GAA (0.51) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL9056936 | 0.87 | GAA (0.50) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL9059369 | 0.86 | GAA (0.49) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL8817744 | 0.86 | NPSR1 (0.45) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL9220408 | 0.85 | GAA (0.47) | GAANPSR1TP53MAPTALDH1A1 | |
| SCHEMBL8809108 | 0.85 | GAA (0.48) | GAANPSR1TP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420348-A | Enzyme inhibitors | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0447116-B1 | Urea derivatives, their production, and pharmaceutical compositions containing them | YAMANOUCHI PHARMA CO LTD (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5258405-A | Acetyl coenzyme A cholesterol acetyltransferase inhibitors for cardiovascular disorders and atherosclerosis and antilipemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
| EP-0447116-A1 | Urea derivatives, their production, and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-09-18 | — | — | EP | disclosed |