SCHEMBL9221973

SCHEMBL9221973

C=CC(=O)OC(C)CNC(=O)CCc1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 5/20 0.43
▸ KMT2A Q03164 3/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ MAOB P27338 3/20 0.41
▸ MAOA P21397 2/20 0.41
▸ ACHE P22303 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.36
▸ LMNA P02545 2/20 0.36
▸ AGTR1 P30556 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ NR1H2 P55055 1/20 0.33
▸ GSK3B P49841 2/20 0.32
▸ HPGD P15428 2/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ NPC1 O15118 1/20 0.30
▸ RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9227024 0.86 GAA (0.34) GAAKMT2AMEN1MAOBMAOA
SCHEMBL9226822 0.85 KMT2A (0.48) GAAKMT2AMEN1MAOBMAOA
SCHEMBL9225045 0.83 KMT2A (0.47) GAAKMT2AMEN1MAOBMAOA
SCHEMBL10395151 0.81 GAA (0.35) GAAKMT2AMEN1MAOBMAOA
SCHEMBL9228497 0.81 GAA (0.35) GAAKMT2AMEN1MAOBMAOA
SCHEMBL10470076 0.80 GAA (0.47) GAAKMT2AMEN1MAOBMAOA
SCHEMBL10395582 0.80 GAA (0.34) GAAKMT2AMEN1MAOBMAOA
SCHEMBL25409880 0.79 GAA (0.39) GAAKMT2AMEN1MAOBMAOA
SCHEMBL8160946 0.79 KMT2A (0.55) GAAKMT2AMEN1MAOBMAOA
SCHEMBL21808905 0.79 GAA (0.38) GAAKMT2AMEN1MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5476882-A Containing 2,2,6,6-tetraalkylpiperidine derivative CIBA-GEIGY CORPORATION (US) 1995-12-19 — — US disclosed
US-5274016-A Crosslinked polyolefin core and stabilizer of a 2,2,6,6-tetramethylpiperidine derivative having at least one ethylenic double bone CIBA-GEIGY CORPORATION (US) 1993-12-28 — — US disclosed
EP-0226538-B1 LIGHT STABILIZED POLYMER MICROPARTICLES Ciba SC Holding AG (CH) 1991-09-11 — — EP disclosed
EP-0226538-A2 Light stabilized polymer microparticles CIBA-GEIGY AG (CH) 1987-06-24 — — EP disclosed
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