Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylstilbestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 14/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 11/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylstilbestrol SCHEMBL27372002 | 1.00 | ESR1 (1.00) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL6542190 | 1.00 | ESR1 (1.00) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL9224 | 1.00 | ESR1 (1.00) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL28317397 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL27619582 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL28180301 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL17594535 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL11333418 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL21351798 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL27692822 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 364803 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260150302-A1 | HYBRID BONDING STRUCTURE AND MACHINE LEANING ACCELERATOR | SK Hynix Inc. (KR) | 2026-05-28 | — | — | US | claimed |
| CN-122082046-A | Method for selectively separating valuable metals from waste lithium battery anode material | — | 2026-05-26 | — | — | CN | claimed |
| CN-122091688-A | Secondary battery, battery module, battery pack, and power consumption device | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076393-A | Aminated lignin-based functional material and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122079129-A | Preparation method of biomass hard carbon anode material based on deep eutectic solvent treatment and application of biomass hard carbon anode material in sodium ion battery anode | — | 2026-05-26 | — | — | CN | claimed |
| CN-115906686-B | Large attack angle nonlinear separation flow aerodynamic force correction method | 中国运载火箭技术研究院 | 2026-05-22 | — | — | CN | claimed |
| WO-2026107437-A1 | SYNERGY OF A COMPLEMENTARY IONIC BIOGEL NETWORK FOR NEUROHAPTICS | THE PENN STATE RESEARCH FOUNDATION (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| CN-122057081-A | PDRN-loaded collagen microgel and preparation method and application thereof | 长春中医药大学 | 2026-05-19 | — | — | CN | claimed |
| EP-0050139-A1 | WORKING SAILS AND METHODS FOR FURLING THEM. | STEVENSON WILLIAM H IV | 1982-04-28 | — | — | EP | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| WO-1981002874-A1 | WORKING SAILS AND METHODS FOR FURLING THEM WHILE ALOFT | STEVENSON W | 1981-10-15 | — | — | WO | claimed |
| US-4288538-A | SIMULTANEOUS ENZYME CONVERSION AND IMMUNOASSAY OF STEROID CONJUGATES | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1981-09-08 | — | — | US | claimed |
| EP-0015637-A1 | Method for enhancing growth rate and feed efficiency of ruminants | AMERICAN CYANAMID COMPANY (US) | 1980-09-17 | — | — | EP | claimed |
| EP-0010964-A1 | Ravidomycin, process of preparation and pharmaceutical compositions containing same | AYERST, MCKENNA AND HARRISON INC. (CA) | 1980-05-14 | — | — | EP | claimed |
| US-4116825-A | ADSORPTION WITH CLAY | INTERNATIONAL TELEPHONE AND TELEGRAPH CORP. (US) | 1978-09-26 | — | — | US | claimed |
| US-4069307-A | Drug-delivery device comprising certain polymeric materials for controlled release of drug | ALZA CORPORATION (US) | 1978-01-17 | — | — | US | claimed |
| US-4009266-A | METHOD OF TREATMENT OF NEMATODE PARASITE INFECTIONS IN DOMESTIC ANIMALS | AYALEW LIYEW | 1977-02-22 | — | — | US | claimed |
| US-3962430-A | Sterilization of solid non-electrolyte medicinal agents employing sodium chloride | MERCK & CO., INC. (US) | 1976-06-08 | — | — | US | claimed |