Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylstilbestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 14/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 11/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylstilbestrol SCHEMBL27372002 | 1.00 | ESR1 (1.00) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL6542190 | 1.00 | ESR1 (1.00) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL9223 | 1.00 | ESR1 (1.00) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL28317397 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL27619582 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL28180301 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL17594535 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL11333418 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL21351798 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 | |
| Diethylstilbestrol SCHEMBL27692822 | 0.97 | ESR1 (0.95) | ESR1ESR2NR1I2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 43324 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209439-B | Cereblon protein modulators | Saint Jude Children's Research Hospital Ltd. (US) | 2026-05-26 | — | — | CN | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-3978473-B1 | COMPOUND CONTAINING AN INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF | BEIJING AN JIAN XI BIO MEDICAL TECH CO LTD (CN) | 2026-05-06 | — | — | EP | claimed |
| EP-4735116-A2 | ANTI-TRAILR2 ANTIGEN-BINDING PROTEINS AND USES THEREOF | ODYSSEY THERAPEUTICS, INC. (US) | 2026-05-06 | — | — | EP | claimed |
| US-20260109699-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2026-04-23 | — | — | US | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| US-20260103758-A1 | METHODS AND BIOMARKERS FOR TREATING BREAST CANCER | KING ABDULAZIZ UNIVERSITY (SA) | 2026-04-16 | — | — | US | claimed |
| EP-3515892-B1 | COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| EP-4711364-A1 | FUSED PYRROLE RING OR FUSED PYRIDINE RING COMPOUND | Pharmaengine, Inc. (TW) | 2026-03-18 | — | — | EP | claimed |
| US-4529713-A | Radioactive stilbene derivatives in radioimmunoassay | ROUSSEL UCLAF (FR) | 1985-07-16 | — | — | US | claimed |
| US-4380534-A | WAXES, STEROIDS, ALKALOIDS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1983-04-19 | — | — | US | claimed |
| EP-0015637-B1 | METHOD FOR ENHANCING GROWTH RATE AND FEED EFFICIENCY OF RUMINANTS | AMERICAN CYANAMID COMPANY (US) | 1983-03-09 | — | — | EP | claimed |
| EP-0069018-A2 | Iodine labelled radioactive stilbene derivatives, process and intermediates for their preparation, and their use in radioimmuno assays | ROUSSEL-UCLAF (FR) | 1983-01-05 | — | — | EP | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| EP-0015637-A1 | Method for enhancing growth rate and feed efficiency of ruminants | AMERICAN CYANAMID COMPANY (US) | 1980-09-17 | — | — | EP | claimed |
| US-4208433-A | TREATING WITH A SYNERGISTIC SOLID | BARHAM HAROLD NATHAN (US) | 1980-06-17 | — | — | US | claimed |
| EP-0010964-A1 | Ravidomycin, process of preparation and pharmaceutical compositions containing same | AYERST, MCKENNA AND HARRISON INC. (CA) | 1980-05-14 | — | — | EP | claimed |
| US-4069307-A | Drug-delivery device comprising certain polymeric materials for controlled release of drug | ALZA CORPORATION (US) | 1978-01-17 | — | — | US | claimed |
| US-4009266-A | METHOD OF TREATMENT OF NEMATODE PARASITE INFECTIONS IN DOMESTIC ANIMALS | AYALEW LIYEW | 1977-02-22 | — | — | US | claimed |