Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CTSA | P10619 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617039 | 0.89 | KMT2A (0.54) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL30232579 | 0.89 | KMT2A (0.54) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL2789512 | 0.86 | KMT2A (0.54) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1989522 | 0.85 | PTGER1 (0.46) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1989523 | 0.85 | PTGER1 (0.46) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL13196105 | 0.84 | KMT2A (0.46) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9222660 | 0.82 | KMT2A (0.50) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL615095 | 0.79 | MAPT (0.46) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL3963434 | 0.78 | KMT2A (0.43) | KMT2AGAAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4307252 | 0.77 | ACP1 (0.42) | KMT2AGAAALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358399-B2 | Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine | CHEMI SPA (IT) | 2008-04-15 | — | — | US | disclosed |
| US-7358399-B2 | Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine | CHEMI SPA (IT) | 2008-04-15 | — | — | US | disclosed |
| US-5382600-A | 3,3-diphenylpropylamines and pharmaceutical compositions thereof | PHARMACIA AKTIEBOLAG (SE) | 1995-01-17 | — | — | US | disclosed |
| EP-0325571-B1 | NEW AMINES, THEIR USE AND PREPARATION | Kabi Pharmacia AB (SE) | 1991-08-07 | — | — | EP | disclosed |
| EP-0354234-A1 | NEW AMINES, THEIR USE AND PREPARATION | KabiVitrum AB (SE) | 1990-02-14 | — | — | EP | disclosed |
| WO-1989006644-A1 | NEW AMINES, THEIR USE AND PREPARATION | KABIVITRUM AB (SE) | 1989-07-27 | — | — | WO | disclosed |
| EP-0325571-A1 | New amines, their use and preparation | Kabi Pharmacia AB (SE) | 1989-07-26 | — | — | EP | disclosed |