Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | PGK2 | P07205 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.43 |
| ▸ | PGD | P52209 | 3/20 | 0.43 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.43 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL8180825 | 0.95 | PGK1 (0.47) | PGK1PGK2LPAR1LPAR5PGD | |
| Glycine SCHEMBL7202269 | 0.95 | PGK1 (0.50) | PGK1PGK2LPAR1LPAR5PGD | |
| Alcohol SCHEMBL28123008 | 0.88 | LPAR5 (0.51) | PGK1PGK2LPAR1LPAR5PGD | |
| Hydrogen Peroxide SCHEMBL27990255 | 0.84 | PGK1 (0.56) | PGK1PGK2LPAR1LPAR5PGD | |
| Butyric Acid SCHEMBL23069514 | 0.83 | LPAR1 (0.50) | PGK1PGK2LPAR1LPAR5PGD | |
| SCHEMBL213379 | 0.82 | PGK1 (0.52) | PGK1PGK2LPAR1LPAR5PGD | |
| SCHEMBL7340 | 0.82 | PGK1 (0.52) | PGK1PGK2LPAR1LPAR5PGD | |
| SCHEMBL7341 | 0.82 | PGK1 (0.52) | PGK1PGK2LPAR1LPAR5PGD | |
| SCHEMBL6655023 | 0.82 | PGK1 (0.52) | PGK1PGK2LPAR1LPAR5PGD | |
| SCHEMBL14278848 | 0.82 | PGK1 (0.52) | PGK1PGK2LPAR1LPAR5PGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645962-A4 | METHODS AND COMPOSITIONS FOR ENHANCING CARBON FIXATION IN PLANTS. | NONOMURA ARTHUR M (US) | 1995-07-05 | — | — | EP | disclosed |
| EP-0645962-A1 | METHODS AND COMPOSITIONS FOR ENHANCING CARBON FIXATION IN PLANTS | NONOMURA, Arthur M. (US) | 1995-04-05 | — | — | EP | disclosed |
| WO-1994000009-A1 | METHODS AND COMPOSITIONS FOR ENHANCING CARBON FIXATION IN PLANTS | NONOMURA ARTHUR M (US) | 1994-01-06 | — | — | WO | disclosed |