SCHEMBL9226641

SCHEMBL9226641

CCCOc1ccc(-c2ccc(-c3ccc(OC(F)F)c(F)c3)c(F)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARA P10276 1/20 0.41
RARB P10826 1/20 0.41
FFAR1 O14842 2/20 0.37
PPARD Q03181 1/20 0.37
FPR2 P25090 1/20 0.36
ERN1 O75460 1/20 0.36
MAOB P27338 2/20 0.36
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
MGAM O43451 4/20 0.35
GAA P10253 4/20 0.35
SI P14410 4/20 0.35
MGAM2 Q2M2H8 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9227276 0.96 RARA (0.39) RARARARBFFAR1PPARDFPR2
SCHEMBL9228557 0.95 RARB (0.46) RARARARBPPARDCYP3A4CYP2D6
SCHEMBL9220464 0.94 RARA (0.45) RARARARBFPR2ERN1MAOB
SCHEMBL9228096 0.93 RARB (0.45) RARARARBPPARDCYP3A4CYP2D6
SCHEMBL9228687 0.92 RARB (0.44) RARARARBPPARDCYP3A4CYP2D6
SCHEMBL9227139 0.92 RARB (0.44) RARARARBPPARDCYP3A4CYP2D6
SCHEMBL9227318 0.92 RARB (0.44) RARARARBPPARDCYP3A4CYP2D6
SCHEMBL9227208 0.91 RARA (0.44) RARARARBFFAR1PPARDCYP3A4
SCHEMBL9228824 0.90 FFAR1 (0.42) FFAR1PPARDNPC1ALDH1A1RAB9A
SCHEMBL9220465 0.89 RARB (0.43) RARARARBFFAR1PPARDCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0413785-B1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS MERCK PATENT GMBH (DE) 1995-12-20 EP disclosed
EP-0413785-A1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS. MERCK PATENT GMBH (DE) 1991-02-27 EP disclosed
WO-1990009420-A1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-08-23 WO disclosed