Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758343 | 1.00 | HTR1A (0.58) | HTR1ADRD2DRD3RENCHRM2 | |
| SCHEMBL8732011 | 1.00 | HTR1A (0.58) | HTR1ADRD2DRD3RENCHRM2 | |
| SCHEMBL1361879 | 0.95 | HTR1A (0.61) | HTR1ADRD2DRD3RENCHRM2 | |
| SCHEMBL1361883 | 0.95 | HTR1A (0.61) | HTR1ADRD2DRD3RENCHRM2 | |
| SCHEMBL1361881 | 0.95 | HTR1A (0.61) | HTR1ADRD2DRD3RENCHRM2 | |
| SCHEMBL1559925 | 0.95 | HTR1A (0.61) | HTR1ADRD2DRD3RENCHRM2 | |
| SCHEMBL8363248 | 0.95 | HTR1A (0.61) | HTR1ADRD2DRD3RENCHRM2 | |
| Hydrochloric Acid SCHEMBL1558407 | 0.93 | HTR1A (0.60) | HTR1ADRD2DRD3RENCHRM2 | |
| Hydrochloric Acid SCHEMBL1361251 | 0.93 | HTR1A (0.60) | HTR1ADRD2DRD3RENCHRM2 | |
| Hydrochloric Acid SCHEMBL1362123 | 0.93 | HTR1A (0.60) | HTR1ADRD2DRD3RENCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641787-A1 | 2H-naphth[2,3-b]-1,4-oxazine derivatives, their preparation and their use as serotonin 1D (5-HT10) receptor agonists | SANDOZ LTD. (CH) | 1995-03-08 | — | — | EP | disclosed |
| US-4656167-A | Naphthoxazines and their use as psychostimulating and antidepressant agents | SANDOZ LTD. (CH) | 1987-04-07 | — | — | US | disclosed |