Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.37 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL28173644 | 1.00 | USP2 (0.41) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL2076959 | 1.00 | USP2 (0.41) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL21332591 | 1.00 | USP2 (0.41) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL5698237 | 0.96 | USP2 (0.39) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL1031790 | 0.96 | USP2 (0.39) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Valine SCHEMBL23610284 | 0.95 | SLC7A5 (0.50) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Valine SCHEMBL28338552 | 0.95 | SLC7A5 (0.50) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL1537268 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL103941 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 | |
| Threonine SCHEMBL5710205 | 0.92 | USP2 (0.47) | USP2SLCO1B1SLC7A5SLC1A1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672064-A1 | OP-3-INDUCED MORPHOGENESIS | CREATIVE BIOMOLECULES, INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994010203-A2 | OP-3-INDUCED MORPHOGENESIS | CREATIVE BIOMOLECULES, INC. (US) | 1994-05-11 | — | — | WO | disclosed |